Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
Top Medical Research Studies
8
Melatonin improves MS-related symptoms
We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.
This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.
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8
Melatonin improves MS-related symptoms
We explored the effects of a 12-week melatonin treatment in individuals with multiple sclerosis (MS), focusing on postural stability, walking performance, and overall quality of life. Our study involved 27 participants divided into two groups: one received melatonin while the other got a placebo.
After the intervention, we observed notable improvements in dynamic balance and walking performance among those taking melatonin. Additionally, participants reported better sleep quality, reduced fatigue, and less neuropathic pain.
Overall, melatonin appears to be a supportive treatment option for addressing some symptoms associated with MS.
After the intervention, we observed notable improvements in dynamic balance and walking performance among those taking melatonin. Additionally, participants reported better sleep quality, reduced fatigue, and less neuropathic pain.
Overall, melatonin appears to be a supportive treatment option for addressing some symptoms associated with MS.
Read More
7
Melatonin improves balance and strength
We investigated the effects of melatonin on postural balance and muscle strength in individuals with multiple sclerosis. Fourteen participants took either melatonin or a placebo before bedtime. The next morning, we measured their balance, leg strength, pain levels, sleep quality, and fatigue perception.
We found that acute melatonin intake was safe and showed promising results in improving dynamic postural stability and lower-extremity muscle strength. This suggests that melatonin may help alleviate some challenges faced by those with this condition.
We found that acute melatonin intake was safe and showed promising results in improving dynamic postural stability and lower-extremity muscle strength. This suggests that melatonin may help alleviate some challenges faced by those with this condition.
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Most Useful Reviews
9
Effective treatment
1 people found this helpful
I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!
Read More
7.5
Improved sleep quality
1 people found this helpful
The difficulty I experienced falling asleep has improved significantly. I purchased this to help with sleep issues before my period, and it was challenging to manage day and night. Taking 1 to 2 tablets before bedtime allowed me to drift off in about half an hour to an hour, which was highly effective. I was uncertain about needing a sleeping pill, but this product has proven beneficial. I'm nearly out and will be ordering more.
Read More
9
Reduced sleeplessness
I was struggling to get enough sleep, so I purchased this product to improve my sleep. Gradually, my sleeplessness is diminishing. I intend to continue using it. Thank you!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9.5
Effective early diagnosis biomarkers identified
We explored how plasma metabolites can help us diagnose chronic kidney disease (CKD) and IgA nephropathy (IgAN) early on. By analyzing blood samples using advanced techniques, we found that melatonin itself can identify early CKD with over 95% accuracy.
Additionally, combining melatonin with tryptophan achieved a remarkable 100% accuracy for CKD diagnoses. Indole-3-lactic acid also showed great potential in distinguishing IgAN in CKD patients, reaching over 85% accuracy for early IgAN diagnosis.
Additionally, combining melatonin with tryptophan achieved a remarkable 100% accuracy for CKD diagnoses. Indole-3-lactic acid also showed great potential in distinguishing IgAN in CKD patients, reaching over 85% accuracy for early IgAN diagnosis.
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9
Melatonin improves MS-related functions
We investigated how melatonin supplementation impacts motor skills and cognitive function in patients with multiple sclerosis. In a controlled trial, 27 participants were divided into a melatonin group and a placebo group for a 12-week period.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
Read More
9
We explored how melatonin affects rheumatoid arthritis-related muscle atrophy. By analyzing its anti-inflammatory properties, we found that melatonin can significantly decrease inflammation in rheumatoid synovial fibroblasts and enhance muscle cell growth.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
Read More
9
Melatonin shows promise in MS treatment
We investigated how melatonin may influence autoimmune disorders, specifically in a mouse model of multiple sclerosis. By combining melatonin with methylprednisolone, a common glucocorticoid treatment, we noticed a protective effect in reducing neuroinflammation. This combination therapy not only decreased harmful immune cells in the central nervous system but also shifted the immune response towards a more regulated state.
Notably, melatonin seems to improve the effects of methylprednisolone, suggesting it could be a promising complement in treating relapses of multiple sclerosis.
Notably, melatonin seems to improve the effects of methylprednisolone, suggesting it could be a promising complement in treating relapses of multiple sclerosis.
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9
Melatonin improves rheumatoid arthritis treatment
In our exploration of melatonin's potential in rheumatoid arthritis (RA) treatment, we utilized hyalurosomes within a collagen gel to enhance its therapeutic effects. The study involved both laboratory and animal testing, showing that melatonin encapsulated in these carriers significantly improved joint healing and cartilage repair in rats.
While traditional RA treatments often have limited effectiveness and side effects, our findings suggest that this innovative approach may offer a safer alternative. Importantly, no adverse interactions were found, indicating a promising future for melatonin in RA management.
While traditional RA treatments often have limited effectiveness and side effects, our findings suggest that this innovative approach may offer a safer alternative. Importantly, no adverse interactions were found, indicating a promising future for melatonin in RA management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective treatment
1 people found this helpful
I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!
Read More
7.5
Improved sleep quality
1 people found this helpful
The difficulty I experienced falling asleep has improved significantly. I purchased this to help with sleep issues before my period, and it was challenging to manage day and night. Taking 1 to 2 tablets before bedtime allowed me to drift off in about half an hour to an hour, which was highly effective. I was uncertain about needing a sleeping pill, but this product has proven beneficial. I'm nearly out and will be ordering more.
Read More
9
Reduced sleeplessness
I was struggling to get enough sleep, so I purchased this product to improve my sleep. Gradually, my sleeplessness is diminishing. I intend to continue using it. Thank you!
Read More
6
Enhanced sleep experience
I regularly purchase this for my son, who has an autoimmune disorder. My son struggled with sleep, but after starting this melatonin at about 15, his sleep quality improved. Although mornings are still tough, he now falls asleep more easily and wakes up feeling better. This product is truly aiding his situation.
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2
Leg swelling issue
I initially tried melatonin for my sleep disorder. While it helped me fall asleep, I often found myself waking up to use the toilet. Additionally, it caused swelling in my legs, leading to discomfort the following day. Now, I've switched to a different brand with lower melatonin content, and I'm no longer experiencing leg pain.
Read More
Frequently Asked Questions
6
Enhanced sleep experience
I regularly purchase this for my son, who has an autoimmune disorder. My son struggled with sleep, but after starting this melatonin at about 15, his sleep quality improved. Although mornings are still tough, he now falls asleep more easily and wakes up feeling better. This product is truly aiding his situation.
9
Reduced sleeplessness
I was struggling to get enough sleep, so I purchased this product to improve my sleep. Gradually, my sleeplessness is diminishing. I intend to continue using it. Thank you!
7.5
Improved sleep quality
1 people found this helpful
The difficulty I experienced falling asleep has improved significantly. I purchased this to help with sleep issues before my period, and it was challenging to manage day and night. Taking 1 to 2 tablets before bedtime allowed me to drift off in about half an hour to an hour, which was highly effective. I was uncertain about needing a sleeping pill, but this product has proven beneficial. I'm nearly out and will be ordering more.
9
Effective treatment
1 people found this helpful
I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!
2
Leg swelling issue
I initially tried melatonin for my sleep disorder. While it helped me fall asleep, I often found myself waking up to use the toilet. Additionally, it caused swelling in my legs, leading to discomfort the following day. Now, I've switched to a different brand with lower melatonin content, and I'm no longer experiencing leg pain.
6
Moderate sleep aid
1 people found this helpful
I wake frequently during the night due to sleep disorders caused by menopause. After trying this product, I managed to fall asleep, but I still wake up a couple of times during the night. Starting with half a tablet seemed fine, yet even one tablet didn't change that. I did not experience any side effects, though.
9
Melatonin improves MS-related functions
We investigated how melatonin supplementation impacts motor skills and cognitive function in patients with multiple sclerosis. In a controlled trial, 27 participants were divided into a melatonin group and a placebo group for a 12-week period.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
The results were promising: the melatonin group showed improvements in knee muscle strength, manual dexterity, and balance, alongside better mood and cognitive performance. This suggests that melatonin may be beneficial for enhancing quality of life in those managing multiple sclerosis symptoms.
8
We explored the potential benefits of melatonin in treating rheumatoid arthritis complicated by interstitial lung disease. Our investigation found that low levels of melatonin in the blood were linked to increased disease severity in patients. In mouse models, melatonin appeared to ease arthritis symptoms, bone damage, and lung fibrosis. Additionally, we noted that melatonin influenced the expression of specific clock genes in lung cells, which may help dampen inflammation. Overall, melatonin shows promise, though further research is needed to fully understand its effects in humans.
9
We explored how melatonin affects rheumatoid arthritis-related muscle atrophy. By analyzing its anti-inflammatory properties, we found that melatonin can significantly decrease inflammation in rheumatoid synovial fibroblasts and enhance muscle cell growth.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
Our research included the use of a collagen-induced arthritis mouse model, showing improvements in swelling and muscle strength after melatonin treatment. This study highlights melatonin’s potential in combating muscle atrophy and fostering muscle growth in autoimmune conditions like rheumatoid arthritis.
7
We explored how circadian rhythm disruptions worsen autoimmune uveitis by affecting Treg cells' stability and function. Our research highlighted that the core clock gene, Per1, plays a crucial role in maintaining Treg cell metabolism and immune regulation.
Melatonin was previously shown to have therapeutic effects in autoimmune uveitis. However, this study emphasizes the necessity of regular circadian rhythms for optimal Treg function, suggesting that melatonin's benefits may be linked to these biological rhythms.
Overall, the findings indicate that while melatonin has potential, circadian rhythm consistency is fundamental to managing autoimmune disorders.
Melatonin was previously shown to have therapeutic effects in autoimmune uveitis. However, this study emphasizes the necessity of regular circadian rhythms for optimal Treg function, suggesting that melatonin's benefits may be linked to these biological rhythms.
Overall, the findings indicate that while melatonin has potential, circadian rhythm consistency is fundamental to managing autoimmune disorders.
References
- Jallouli S, Ghroubi S, Bouattour N, Sakka S, Damak M, et al. Effects of Melatonin Supplementation on Muscle Strength, Manual Dexterity, and Postural Balance in Patients Living with Multiple sclerosis - A Randomized Controlled Trial. J Diet Suppl. 2025;22:236. doi:10.1080/19390211.2024.2449030
- Zhu W, Chen G, Xiao Z, Wang M, Li Z, et al. Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function. Adv Sci (Weinh). 2025;12:e2400004. doi:10.1002/advs.202400004
- Jallouli S, Jallouli D, Damak M, Sakka S, Ghroubi S, et al. 12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial. Metab Brain Dis. 2024;40:52. doi:10.1007/s11011-024-01428-2
- Huo Y, Gao Y, Li B, Zhang P, Liu H, et al. Analysis of how melatonin-upregulated clock genes PER2 and CRY2 alleviate rheumatoid arthritis-associated interstitial lung disease. Eur J Pharmacol. 2025;986:177136. doi:10.1016/j.ejphar.2024.177136
- Su CM, Tsai CH, Chen HT, Wu YS, Yang SF, et al. Melatonin Regulates Rheumatoid Synovial Fibroblasts-Related Inflammation: Implications for Pathological Skeletal Muscle Treatment. J Pineal Res. 2024;76:e13009. doi:10.1111/jpi.13009
- Jallouli S, Ghroubi S, Damak M, Sakka S, Elleuch MH, et al. 12-week melatonin supplementation improved dynamic postural stability and walking performance in persons living with multiple sclerosis: A randomized controlled trial. Behav Brain Res. 2025;476:115191. doi:10.1016/j.bbr.2024.115191
- Álvarez-López AI, Álvarez-Sánchez N, Cruz-Chamorro I, Santos-Sánchez G, Ponce-España E, et al. Melatonin synergistically potentiates the effect of methylprednisolone on reducing neuroinflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. J Autoimmun. 2024;148:103298. doi:10.1016/j.jaut.2024.103298
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. doi:10.1016/j.ijpharm.2024.124449
- Aslany N, Vahedpour Z, Rahimi H, Masjedi M, Motedayyen H. Effects of melatonin on disease improvement and serum levels of pro-inflammatory cytokines in patients with non-atypical endometrial hyperplasia. J Immunoassay Immunochem. 2024;45:382. doi:10.1080/15321819.2024.2371583
- Liu Y, Wang F, Cheng B, Zhou G. Melatonin improves salivary gland damage and hypofunction in pSS by inhibiting IL-6/STAT3 signaling through its receptor-dependent manner. Mol Immunol. 2024;169:10. doi:10.1016/j.molimm.2024.02.012
- Jallouli S, Ghroubi S, Sakka S, Ben Dhia I, Damak M, et al. Effects of a nighttime melatonin ingestion on dynamic postural balance and muscle strength the following morning in people living with multiple sclerosis: A preliminary study. Clin Neurol Neurosurg. 2024;238:108165. doi:10.1016/j.clineuro.2024.108165
- Fu X, Luo ZX, Yin HH, Liu YN, Du XG, et al. Metabolomics study reveals blood biomarkers for early diagnosis of chronic kidney disease and IgA nephropathy: A retrospective cross-sectional study. Clin Chim Acta. 2024;555:117815. doi:10.1016/j.cca.2024.117815
- Razmaray H, Nasiri E, Vakilipour P, Morsali S, Moradi A, et al. The effects of melatonin supplementation on neurobehavioral outcomes and clinical severity in rodent models of multiple sclerosis; a systematic review and meta-analysis. Inflammopharmacology. 2024;32:927. doi:10.1007/s10787-023-01414-7
- Morsali S, Sabahi Z, Kakaei J, Hakimzadeh Z, Hamidi S, et al. Clinical efficacy and safety of melatonin supplementation in multiple sclerosis: a systematic review. Inflammopharmacology. 2023;31:2213. doi:10.1007/s10787-023-01271-4
- Xu Q, Cheung RTF. Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects. Brain Behav. 2023;13:e3118. doi:10.1002/brb3.3118
- de Carvalho JF, Skare TL. Melatonin supplementation improves rheumatological disease activity: A systematic review. Clin Nutr ESPEN. 2023;55:414. doi:10.1016/j.clnesp.2023.04.011
